antibody discovery

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45-1 Ramsey Road, San Ramon , CA
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+1 5166698109
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antibody discovery Website
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Health & Wellness, Other Medical
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Creative Biolabs has proudly developed the unique Native™ Antibody Discovery Platform to develop native monoclonal antibodies using antigen-specific B lymphocytes cytometry technology.

Current in vitro antibody display methods cannot provide antibodies with naturally paired heavy chain and light chain. For technical reasons, the natural pairings of heavy and light chains found in antibody-producing B cells are not retained as the combinatorial libraries are constructed, leading to a random pairing of VH and VL in those de novo or naïve human antibody libraries. This could potentially lead to the generation of antibody molecules that have suboptimal solubility or other biophysical characteristics. Thereby, antibodies derived from these technologies most likely do not represent the naturally cognate heavy and light chains.

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